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» Macrolide glycosyltransferase

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  • Catalog #
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    Price
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  • PRO-E0066-1 mg
    1 mg
    £10.00
  • PRO-E0066-10 mg
    10 mg
    £70.00
  • PRO-E0066-100 mg
    100 mg
    £450.00
  • PRO-E0066-1 g
    1 g
    £2,700.00

Catalogue No.:
PRO-E0066

LOT:
2008-0066

Source Organism:
Streptomyces lividans DSMZ 46482

Enzyme Properties

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EC No.:
2.4.1.-

Synonyms:
Oleandomycin glycosyltransferase

Nomenclature:
CAZy [GT1, glycosyltransferase family 1, member of fold GT-B], UGT102A1, MGT

Specific Activity:
NOTE: this product has been produced and is awaiting assay. It is thus currently available for purchase by the mg only

Accession No.:
DQ185434.1, Q3LRZ5

Molecular Weight:
45551.4 Da

Biological Function:
Glycosylation (glucosylation) of macrolide antibiotics including (in order of decreasing activity) lankamycin, chalcomycin, rosaramicin, methymycin, pikromycin, erythromycin, oleandomycin, azithromycin, tylosin and spiramycin (data taken from Cundliffe E (1991) Antimicrob. Agents Chemother. 36, 348–352)

Comments:
This enzyme is identical to Q9ADH3 from Streptomyces coelicolor A3(2) and 99 % identical to Q54387 from another strain of Streptomyces lividans

Primary Sequence

KRKELHETSRLAYGRRMTTRPAHIAMFSIALHGHVNPSLEVIRELVARGHRVTYAIPPLLADKVAEAGAE
PKLWNSTLPGPDADPEAWGSTLLDNVEPFLADAIQSLPQLAQAYEGDEPDLVLHDIASYTARVLGRRWEV
PVISLSPCMVAWEGYEQEVGEPMWEEPRKTERGQAYYARFHAWLEENGITDHPDPFIGRPDRSLVLIPKA
LQPHADRVDETTYTFVGACQGDRTAEGDWARPEGAEKVVLVSLGSAFTKQPAFYRECVRAFGELPGWHTV
LQVGRHVDPAELGDVPDNVEVRTWVPQLAILQQADLFVTHAGAGGSQEGLATATPMIAVPQAADQFGNAD
MLQGLGVARTLPTEEATAKALRTAALALVDDPEVAARLKEIQARMAQEGGTRRAADLIEAELAAARG